Simvastatin use has declined over time due to more potent statins being available and due to numerous drug interactions. Grapefruit juice can inhibit CYP3A4 which will increase the concentrations of simvastatin.

Citalopram is an SSRI used in the management of depression, anxiety, OCD, and PTSD. How do you manage the risk of citalopram causing QTc prolongation? I discuss it further in the podcast. Omeprazole can inhibit CYP2C19 which affects the metabol...

Epoetin alfa is essential exogenous erythropoetin which can stimulate the production of red blood cells. It is critical to ensure adequate iron stores when using EPO. Risks for blood clots, strokes and heart attacks are critical to recognize wi...

Dexamethasone has numerous possible indications such as asthma, chemotherapy-induced nausea and vomiting, and pain associated with inflammation. Dexamethasone is more potent than prednisone. Approximately 0.

On this episode, I discuss sildenafil pharmacology, adverse effects, and important drug interactions. Sildenafil's most common and concerning adverse effect is in relation to its ability to lower blood pressure.

On this episode, I discuss codeine pharmacology and practical clinical practice pearls. Codeine is metabolized by CYP2D6 to the active metabolite morphine. I discuss how this can be affected by genetics as well as other medications.

Dexmedetomidine is a selective alpha-2-adrenergic agonist with sedative characteristics. Dexmedetomidine is commonly used in ICU and procedural sedation, as well as postoperative pain. A few of the more serious adverse effects of dexmedetomidin...

On this episode, I discuss the pharmacology of calcitonin. Calcitonin has an indication for osteoporosis as well as hypercalcemia. When considering drug interactions with calcitonin, recall that it can lower calcium levels which could have a cum...

Rivastigmine is an acetylcholinesterase inhibitor used in the management of certain dementias. I discuss rivastigmine pharmacology on this episode. Weight loss is a potential adverse effect of rivastigmine. It is important to monitor weights.

Caffeine is a commonly used supplement and is found in many food and beverages. I discuss caffeine pharmacology, adverse effects, and drug interactions. Caffeine can inhibit CYP1A2 and also be affected by CYP1A2 inhibitors.