Tizanidine is primarily broken down by CYP1A2. Ciprofloxacin can inhibit CYP1A2 and cause higher tizanidine concentrations.

Tizanidine has a similar classification as clonidine. Pay attention to adverse effects like hypotension and bradycardia.

When patients taking routine tizanidine stop taking it, there is potential for a discontinuation syndrome that may lead to rebound hypertension.

Dry mouth and CNS depression are common adverse effects of tizanidine.