On this episode, I discuss codeine pharmacology and practical clinical practice pearls.

Codeine is metabolized by CYP2D6 to the active metabolite morphine. I discuss how this can be affected by genetics as well as other medications.

Constipation is a problem with codeine and all opioids in general. Education and making a plan with patients to combat this side effect is important.

Codeine is less potent than other opioids such as fentanyl, hydromorphone, and hydrocodone.