Kimberlys harrowing experiences with gastrointestinal issues go back about 10 years. At first she would have random bouts of diarrhea, but be fine for months in between. She didnt seek medical care

Jeff lives with a medical mystery that has stumped doctors in multiple specialties. He experiences episodes that strike about once a week, and leave him almost catatonic. He will become hypersensitive

In 2015 Karen noticed that her right arm was not swinging as normal when she walked. She was sent to a neurologist who quickly diagnosed her with Parkinsons disease (PD), a neurodegenerative disorder

Tyler Roope is a viral TikTok creator living with spinal muscular atrophy type 2 Tyler Roope is a 25 year old TikTok star, who blends comedy and education while advocating on behalf of the disabili

Troy discusses the unique medical needs of the LGBTQ community Troy is a nurse practitioner at a LGBTQ healthcare clinic in Seattle, Washington. He refers to it as gay providers taking care of the

Amelia wasn't diagnosed with her genetic condition myotonia congenita until adulthood Myotonia congenita is a genetic disorder that Amelia recently discovered she has been living with her whole lif

Courtney's mysterious illness remains undiagnosed Courtney refers to herself as a hot potato patient, being passed from specialist to specialist in search of a diagnosis to her mystery illness, but

Andrew, Aimee and Ilana return to update us on their health journeys. This week we kick off the third season of Major Pain by catching up with previous guests! First we'll check in with Andrew,

Andi and Jesse wrap up season 2 of Major Pain by sharing their health updates and reflecting on the past year of the show. Jesse discusses his potential diagnoses of mast cell activation syndrome and

Michelle is unsure when her journey with idiopathic intracranial hypertension (IIH) began. She started experiencing chronic migraines and pulsatile tinnitus in her 20s, which may have been the first s