This episode explores the 2025 CMS final rule changes with a deep dive into how new payment and coding policies—especially around skin substitutes—will impact Chargemaster design, revenue integrity, and reimbursement across hospitals, ASCs, and physician practices. The guests highlight the need for multidisciplinary collaboration, stronger standards, and more innovative use of automation and EHR tools (e.g., order sets, creative forms, charge edits) to ensure compliant billing, protect revenue, and align payer contracting strategies with the new regulatory landscape.