Host Jodi Katz sat down with two women at the forefront of redefining health care as we know it: Liz Josefsberg, Founder & CEO of Target 100 Inc and Sarah Pesce, COO of stealth-mode wellness startup Radence.

Despite wildly different paths—Liz went from Broadway star to Weight Watchers executive, while Sarah pivoted from nurse practitioner to health-tech builder—both share a mission: to help people move from “sick care” to well care.

Liz's early career was center stage—literally. She spent years performing in Showboat and Les Misérables, all while privately battling weight fluctuations. That struggle led her to Weight Watchers, first as a member, then as a team member, and ultimately as their Director of Brand Advocacy. She helped build programs, consulted for the CEO, and guided celebrities like Jennifer Hudson and Charles Barkley through their own wellness transformations.

But Liz wanted more than just the Weight Watchers playbook. She authored Target 100, a behavioral weight loss book that evolved into an app platform connecting hydration tracking, biometrics, and movement. Her mission? To give people a simple, evidence-based way to understand their bodies—and stay in the game without guilt or shame.

Sarah began in cardiology, treating patients already facing chronic illness. It didn’t sit right. She saw an opportunity to move upstream—to build better systems for prevention. That led her to advanced degrees, hospital innovation work, and eventually to launching wellness labs that deliver “digital twins” of users through biomarker testing, wearables, and environmental data.

Now, at Radence, Sarah’s team is developing a member-based preventative screening experience backed by a powerhouse science team. Her focus? Making cutting-edge longevity care accessible, personalized, and understandable—without needing an advanced medical degree to interpret your own labs.

Liz and Sarah agreed on nearly everything: that bio-data is only helpful if it’s explained clearly. That technology is outpacing consumer understanding. That shame is a sales tool used too often—and that emotional support is what most health programs are missing. Whether it’s using AI to build “Liz in your pocket” or designing a membership that meets people where they are, their north star is clarity, context, and compassion.

As Liz put it: “No woman has ever come to me and said she doesn’t know an apple is better than a Snickers. The problem isn’t information. It’s behavior—and how we stay in the game.”