With healthcare organizations expanding across the value chain and blurring boundaries across sectors, Jen, Mindy, and Ryan discuss the trend towards business model and partnership innovation. The episode opens with a discussion of what is driving this change (00:45), specifically consumers, complexity, connected care, cost, the need to create and capturing value, and of course, COVID-19 (04:08). At (06:28) the conversation shifts to discussing a few specific business model and partnership innovation examples, including the Oak Street-One Medical partnership (06:50), the Humana-Dispatch health partnership (08:44), and the Hims/Hers-Privia Health partnership (10:32). Traditional life science companies continue to pursue unique launch partnerships, licensing opportunities, and distribution agreements (11:06), while healthcare organizations are spinning out their in-house technology solutions as independent offerings (12:37). The episode concludes with a discussion of what healthcare leaders should be considering to make these new partnerships and models successful (13:48), including clearly defined goals and success metrics, transparency, and agility.