Welcome to the next episode of The Reveal where we take you inside the mind of a test-taker to deconstruct and connect the dots of a board-style question so you can become a better student, transform how you learn, and excel not only on high-stakes exams, but also in your general medical knowledge. Let’s get started.

What is the most likely cause of acute anemia in an African-American patient with HIV infection who recently began pneumocystis pneumonia prophylaxis?

A) Glucose-6-phosphate-dehydrogenase (G6PD) deficiency

B) Hereditary spherocytosis

C) Paroxysmal nocturnal hemoglobinuria

D) Pyruvate kinase deficiency

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