Guest:

Dr. Prasanna Jagannathan is an Assistant Professor of Medicine in Infectious Diseases and of Microbiology and Immunology at Stanford University. His research focuses on the mechanisms of clinical immunity to malaria. He talks about how repeated exposure to malaria can lead to tolerance without symptoms, promising vaccines and treatments to prevent reinfection, and the role of innate immune cells. He also discusses shifting from religious studies to teaching to medicine, and establishing long-term collaborations with researchers in Uganda.

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The Immunology Science Round Up

Blocking Psoriasis Signaling with Methotrexate – Scientists identified SLC46A2 as an important target for anti-inflammatory intervention in the skin.

Tumor-Infiltrating Tregs – Researchers discovered and validated new master regulators of human tumor-infiltrating Tregs.

T_H9 Cells and Allergic Inflammation – JAK inhibitors may be effective for allergic patients with T_H9 cell expansion.

Gene Editing Primary Lymphocytes – Researchers used a CRISPR ribonucleoprotein mixed with an amphiphilic peptide to increase the yields of edited primary human lymphocytes.

Peptide-Assisted Genome Editing – Scientists demonstrated rapid and efficient editing of primary cells with low cellular toxicity and no significant transcriptional perturbation.

Image courtesy of Dr. Prasanna Jagannathan

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