Guest:

Dr. Vijay Kuchroo is the Samuel L. Wasserstrom Professor of Neurology at Harvard Medical School. His major research interests include the role of co-stimulation in autoimmune diseases, as well as cell surface molecules and regulatory factors that regulate the induction of T cell tolerance and dysfunction. He talks about the conditions necessary to differentiate Th17 cells and their role in autoimmunity. He also discusses his group’s discovery of Tim-3, an inhibitor receptor on T cells which is now being exploited for cancer immunotherapy.

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• Resources for Your T Cell Therapy Research
  
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The Immunology Science Round Up

Disrupting Calcium Homeostasis – Researchers showed that inherited variants in ITPR3 alter physiologically relevant Ca²⁺ signaling responses, driving defects in immune responses.

Light Chain Coherence in Antibodies – Among naturally occurring antibodies that have adapted to particular antigens, those with similar heavy chains usually have similar light chains.

Anti-CTLA-4 Antibodies Reprogram the Tumor Microenvironment – Scientists used single-cell RNA sequencing to dissect the immune response to anti-CTLA-4 blockade.

An Intranasal Booster for Sarbecoviruses – Researchers used a SARS-CoV-2 intranasal spike booster to elicit mucosal immune memory within the respiratory tract.

Image courtesy of Dr. Vijay Kuchroo

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.semantic_ui .ui.table
{
border: 0px solid !important;
}

.semantic_ui .ui.table td
{
padding: 0em;
}#footable_4813 td.ninja_column_0 { text-align: center; }#footable_4813 th.ninja_column_0 { text-align: center; }

#footable_4814 {
font-family: inherit;
font-size: 14px;
}

#footable_parent_4814 thead
{
display: none;
}

#footable_parent_4814 a.nt_edit_link
{
display: none;
}

#footable_parent_4814 td
{
border-color: #fff;
}

#footable_parent_4814 img
{
max-width: 300px;
}

.semantic_ui .ui.table
{
border: 0px solid !important;
}

.semantic_ui .ui.table td
{
padding: 0em;
}













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