Guest:

Dr. Greg Delgoffe is an Associate Professor at the University of Pittsburgh. His lab studies the intersection of metabolism and immunity in cancer. He talks about the metabolism of immune cells in cancer and the effects of nutrients in the tumor microenvironment.

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The Immunology Science Round Up

Microbes in Diabetes Drug Responses – Researchers identified a microbiota-derived enzyme as a potential antidiabetic target.

STING Can Transport Protons – Scientists analyzed STING’s structure, hypothesizing that its transmembrane domain forms a pore capable of proton transport.

cGAS–STING in Neurodegeneration – The cGAS–STING signaling pathway is a critical driver of chronic inflammation and functional decline during aging.

T Cells Can Kill MHC-I Negative Tumor Cells – CD8⁺T cells maintain the capacity to kill tumor cells that are entirely devoid of MHC-I expression.

Image courtesy of Dr. Greg Delgoffe

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