FYI - For Your Innovation

FYI - For Your Innovation


The Evolving World of RNA Editing with Dr. David Nelles

November 08, 2021

As the year comes to an end, we would like to thank everyone who listened to the FYI — For Your Innovation podcast. 2021 was another up and down year, as the world continues to battle the COVID-19 pandemic. In this final episode of 2021, we compiled some of our most interesting podcast episodes for you. Please enjoy this summary and tune back in when we return in 2022 with a new and improved version of FYI.





Key Points From This Episode:
  • Factors that caused CRISPR to dominate the gene editing space.
  • David explains the difference between DNA and RNA, using a football analogy.
  • The goal that David centered his PhD around.
  • Variety that exists amongst RND molecules.
  • Benefits of targeting RNA in diseased cells, rather than DNA.
  • Why RNA lagged behind DNA in terms of technological developments.
  • A theory about the role played by RNA in the past.
  • Methods of RNA editing.
  • Comparing homology directed repair (HDR) and non homologous end joining (NHEJ).
  • David provides a breakdown of the various different guides and enzymes.
  • Three kinds of vector systems, and how they work.
  • Examples of the types of RNAs that exist.
  • What David is excited about in the future of the RNA technology field.