Do cystic fibrosis lung impairment and the COVID-19 virus create the disastrous combination they would seem to make? What do the currently published data say about the clinical effects of the pandemic on people living with CF? How have the safety-mandated lockdowns and clinic closures affected CF care teams’ ability to effectively maintain their patients’ health? What information out there is proved, what’s speculation, and what is simply unknown?  These questions are the focus of this eCysticFibrosis Review Special COVID Edition issue. Lisa Saiman MD, MPH, professor of pediatrics at Columbia University Irving Medical Center, analyzes the current literature investigating these questions and then speaks directly with front-line clinicians about what they’re experiencing as they navigate a disrupted health care system.  See acast.com/privacy for privacy and opt-out information.