CMAJ Podcasts
Genetic Perils: Allopurinol Hypersensitivity Syndrome and Personalized Medicine
Allopurinol hypersensitivity syndrome (AHS) affects approximately 1 in 1,000 patients prescribed allopurinol, with reported mortality rates between 20% and 25%. The risk of AHS is nearly 100 times higher in carriers of the HLA-B*58:01 allele than in nonca