The Dr. Chalmers Show Season #3, episode 6 - Critical information on Erythritol. Heart health and misinformation.  

Dr. Chalmers Show - Erythritol Podcast

Dr. Matt Chalmers [00:00:03] Hey, this is Dr. Matt Chalmers and you're listening to the Dr. Chalmers podcast. We'll be covering how the body actually works so we can fix the things no one else can. 

[00:00:16] This is Dr. Matt Chalmers, I want to come in touch on this Erythritol thing real quick because people are making real bad assumptions, some actually real. So the issue with Erythritol is that the reason that they see it, you're not going to have all of this research in the show notes. The guys go to the show notes and look at all this because I'm going to read you excerpts from it. 

[00:00:36] But all the research in Claremont is going to be in the show notes. What they were doing is they did a cohort study this is what the nature of the nature articles about and they found is a correlated issue that people who had they were testing for heart and stroke issues showed a lot of a Erythritol on their system and that was just one of the causes of things. It was like, Oh, hey, there's a whole lot of this in someone's tissue that must mean that it's that. 

Dr. Matt Chalmers [00:01:04] So they were looking for they were actually looking for anything in patients who are having heart attacks. All right. So it's not as if they went to a. Normal group of people started doing it. All of a sudden they found that this thing was there and then people have heart attacks. 

Dr. Matt Chalmers [00:01:21] It was people they were monitoring and tracking because of heart there were heart attack patients to begin with, and they were trying to figure out, is there a genetic marker? Is there something that is the same in all of these people that maybe we could find and kind of track later? That's where they found it. 

Dr. Matt Chalmers [00:01:40] And so, like, for instance, the where they got this this is the actual study from Cleveland Clinic that they were doing. It says proposed the large research plan to collect blood from patients undergoing heart catheterization or who have had heart cath within one year coming in to outpatient appointment. 

Dr. Matt Chalmers [00:02:01] So these people were already messed up heart wise, and they were trying to figure out all the things that go on when your heart's messed up. They're trying to figure out a way to track it and prevent it. So what they found now was that there was a bunch of erythritol in these people's blood. It was just one of those random things that they weren't really looking for, but they found that's what sparked this whole thing. 

Dr. Matt Chalmers [00:02:25] Here's the problem [00:02:27]the reason the vast majority of them had this issue was because they had a sugar diet, not erythritol diet. [8.2s] What happens is that when you get into sugar toxicity, the Pintos phosphate pathway, the PPV stops working. Right, and it starts breaking down. 

Dr. Matt Chalmers [00:02:47] And when it breaks down again to because of long-term glucose problems, sugar problems that sugary diet problems, it damages this process and it starts producing a resveratrol to protect your blood vessels, which is why when people have damaged heart and damaged blood vessels, they ended up with a lot of Erythritol in their system their body was making it as a byproduct of this broken chemistry. 

Dr. Matt Chalmers [00:03:12] So when we talk about inflammation, this is exactly what we're talking about. [00:03:16]Inflammation is when biochemistry goes awry and it's not working where it's supposed to. When you break the Pinto's phosphate pathway or you over you over glucose, this you put way too much glucose phosphate in this what ends up happening is it starts spooling off all these other free radicals they're going to damage thing. [15.8s]

Dr. Matt Chalmers [00:03:32] And one of the things that does produces Erythritol which I said is cardio protective. So we shouldn't be banning this. We should be accepting more of it and fixing our sugar diet, which is causing the heart attacks and strokes to begin with. 

Dr. Matt Chalmers [00:03:45] So this is the thing. This is not a causative issue. This is a correlative issue. Yes. A lot of people who had protection, strokes, had a reversal of their system doesn't mean that's what caused it. So your body naturally produces a Erythritol. 

Dr. Matt Chalmers [00:03:59] So that's the thing I think people don't understand. It's like, well, it's a sugar chemical. It's not. It's a term that plants, fruits, things produce we make it too. And so that's the thing they sound all these heart attack patients, they found the erythritol and they just decided it was Erythritol that was causing heart attacks, strokes, not anything else. 

Dr. Matt Chalmers [00:04:18] They did. They didn't actually decide that. Everybody said, oh, there's a Erythritol there. And someone just decided that was what's actually causing the problem. But it's not. I want to read you some other stuff that the research program put out because we've been researching it as a curative measure measure for diabetes. 

Dr. Matt Chalmers [00:04:35] We've been seeing it really do beneficial things to the heart, to the blood cells, to the capillaries, the fingers just like that. So, I mean, again, all these give me shoutouts, but I want to kind of go through and read a little bit of that so you kind of get a grasp on some of it. I know that not everybody is like, I read these for fun and I realize. 

Dr. Matt Chalmers [00:04:54] So one of them in there is the effects of Erythritol on endothelial function in patients with type two diabetes. All right. So type two diabetes. Vast majority of the time it's because your body got overstimulated by sugars. You're eating too many sugars we get type two diabetes. Keto diets fix this pretty well for people I can give you that right now. 

Dr. Matt Chalmers [00:05:15] But the Erythritol what it does when people are eating more erythritol because they're on a keto diet or because their doctor said quit eating sugar. And so they started in your research. All this is a study on what is exactly is it doing to the blood vessels, to the to the heart and that sort of thing. 

Dr. Matt Chalmers [00:05:32] So I'll read you the discussion. [00:05:35]Our study provides preliminary information about the effects of erythritol on vascular function that may be useful for designing a randomized study. [7.0s] By the way, any time you're reading research it, it says more research needs to be done. Understand the reason it says that is either one we've had one or two steps. 

Dr. Matt Chalmers [00:05:53] But 99% of the time it's because the people who do the research only get paid when there's research being done. Keep that in mind, because they're always saying, well, look, you know, look at who funded the study. Also understand that every time that says more research needs to be done, recognize that they also are trying to, you know, eats and feed their family. So being away on other like I said, designing new studies. 

Dr. Matt Chalmers [00:06:16] [00:06:16]Erythritol produce acute and chronic improvements betterments Not bad, but good improvements on an in the theory of dependent dilation in small arteries in the fingertip. [12.2s] All right. So what happens with the blood vessels as we start off with the heart and then it goes into a giant pipe and then the pipe gets smaller and smaller and smaller they all have little names, but the smallest ones are your capillaries. Those are the ones in your fingers when you put your finger. That's the thing. 

Dr. Matt Chalmers [00:06:46] [00:06:46]This is also a big deal for people who have Raynaud's. [2.8s] So. Raynaud's is those little capillaries close up too much and your fingers are always freezing cold. You can be sweating and have your hands feeling like they're in ice water. 

Dr. Matt Chalmers [00:07:00] And that's this is a big deal for a lot of people and this is one of those things we see in diabetes as well, because that neuropathy that they're getting in their fingers, in their toes is from the capillaries closing up. 

Dr. Matt Chalmers [00:07:10] And so finding ways to dilate those capillaries is a really important thing. This is where I right now use hyperbaric chambers that cost $10,000 if you want one in your house. And they treat this really well. But if we could find cheaper alternatives, that would be great to to what this is saying is that Erythritol produced positive changes in those small, tiny blood vessels that open up and bring more oxygen and blood to the area, which is obviously a good thing. 

Dr. Matt Chalmers [00:07:38] [00:07:38]It says chronic erythritol also improved central aortic stiffness. [3.3s] So what happens with body tissues is when they get less and less healthy, like as they get older, that type of thing, they start stiffening up and as they stiffen up, that's when they start blacking more. That's when they start tearing. That's when they just don't have the function that you need them to have anymore. 

Dr. Matt Chalmers [00:08:01] So you want them to be like a rubber band, like a healthy were rarer. It stretches a little bit and comes back. It stretches a little bit becomes that the issue with this is that these got really stiff and so when they're really stiff to be pushing against each other in the pressure that gets bad. 

Dr. Matt Chalmers [00:08:14] So we do in fact want aortic stiffness to come down we want the pliability to come back up. [00:08:21]It says in a study using diabetic rats erythritol treatment for 21 days, improved endothelial function and reduced oxidative stress. [7.8s] So for those guys who listen to this, if I do reactive oxidative stress is the number one thing we're all pushing back against but It's another name for inflammation, it's another name for pre radical damage. 

[00:08:41] But the ROS, the reactive oxygen stress is always going to be after spiking and because that's what's killing all of us and that's again chemistry gone awry. Right. So but what this is saying is that in a 21 day study, in 21 days, these diabetic rats, they made diabetic these diabetic rats, all of their function improved, their blood vessel functions got better because it was stripping and blocking out the sugar. 

Dr. Matt Chalmers [00:09:05] In vitro studies suggest that [00:09:07]ERYTHRITOL reduces stress induced endothelial apoptosis and alters the transcription of genes relevant to mitochondrial function. [8.0s] Loss of we stop right there. All right. So in these studies they're looking at if reduce the so apoptosis the cell death when this all just basically explodes think of it that way. 

Dr. Matt Chalmers [00:09:27] So if decreased the damage to the to the actual blood vessels in the the real tissue from normal overstressed like cytotoxicity type stuff where it's super excited breaks it brought back that brought it down and then it altered the transcription of the genes relevance of mitochondrial function. 

Dr. Matt Chalmers [00:09:45] Okay [00:09:46]mitochondria make all of our ATP. [1.8s] The evidence is very phosphate that ATP is what our brain uses, our heart uses our muscles, everything. Runs on it. It's called the currency of the body. The more you have just like money, the more ATP you have, the better off your day is going to be. 

Dr. Matt Chalmers [00:10:02] So you really want to have as much mitochondrial function and ATP production as possible. So this is a good thing. [00:10:09]It also talks about antioxidant production. [1.6s] Here's the problem When people don't understand coupling lies, the better your mitochondria function normally, the more ATP they produce, but the far less antioxidant, I mean, free radicals they produce. 

Dr. Matt Chalmers [00:10:23] So the problems mitochondria is we're going to make each of you no matter what. So if we have we have good conditions, we make a bunch of we have 32 ATP for a citric acid or Krebs cycle function. If we don't have enough things like Hokitika, we don't have a computer, we can't do it. We're going to make eight units of ATP and a bunch of bad chemistry about inflammation, a bunch of free radicals. Okay, so that's what's going on. 

Dr. Matt Chalmers [00:10:47] So we increase mitochondrial function, we make it work BETTER, then that's a really good thing from both a energy and function of the body and a waste product issue. So that's why fixing this is such a good thing. That's why we talk about antioxidant protection. Is there just a lot less free radicals to begin with cell signaling telling the cells how to do. 

Dr. Matt Chalmers [00:11:08] [00:11:08]This present study provides novel information about the relevance of the experimental work to humans. [5.5s] So basically what the saying is that this is a new study. I'll go back and see what it was, but it's it's really helping with pretty much everything. We observe that resveratrol improves. The other part response in this emerging, clinically relevant method for measuring small vessel endothelial function. 

Dr. Matt Chalmers [00:11:31] So again, the blood vessels are healthier with all the new testing they're doing. [00:11:37]The response to events on nitric oxide correlates inversely with risk factors. Particular ditails, diabetes nolis. [7.0s] Nitric oxide dilates blood vessels. Awesome. Lots of bodybuilders use it. I use it. I think it's a fantastic supplement. It's an arginine based muscle, but it really helps oxygenate the area, get waste out and move stuff. And so what we're talking about when it talks about increasing nitric oxide, that's one of the reasons that we see for dilation of blood vessels. So that's what they're talking about. 

Dr. Matt Chalmers [00:12:07] Okay. [00:12:07]It says it is notable that there was no change in flow-mediated dilation on the kendra brachial artery. [6.3s] So as the blood pressure is coming up, as the blood vessels are moving, it's not affecting anything on the other side. [00:12:19]Our results suggest that acute erythritol consumption might have preferential effect on inditual function in smaller arteries and diabetic medications. [8.3s]

Dr. Matt Chalmers [00:12:29] So basically they're saying ether is fertile. It's a really good idea for diabetics because of small vessel capillary blood function. So if you know any diabetics who've been diabetic for a while, you can talk to them. And a lot of them, all of them, a lot of them will tell you that their toes, their toes, their fingertips lose feeling or numb or get cold or heal really slowly if they scratching or cut them. That's what we're talking about. So getting those blood vessels up and out is really, really good idea. You get everything going in. 

[00:13:02] [00:13:02]Erythritol, lowered central pulse pressure and tended to lower carotid-femoral pulse wave velocity these findings suggest reduced stiffness of the central aorta. [8.0s] So all the tests you were showing you and I'll quit reading this is they're highly beneficial to blood vessels. They're not causing heart attacks. They're very well might be preventing them when you see it without having a tie to it and saying,. 

Dr. Matt Chalmers [00:13:25] Oh, why do you ever throttle your system? 

Dr. Matt Chalmers [00:13:27] Oh, because I had an ice cream last night. 

Dr. Matt Chalmers [00:13:29] Oh, cool. We know it's cardioprotective. If you're like, Hey, are you eating a lot of versus all the patient goes, No, I'm not eating any. This should now tell us, Oh, your chemistry's probably broken. BP is broken. We need to go look at this different way. Now, subsidiaries of programs like those type of things where I would start, I would also start doing all sorts of blood panels looking for inflammatory function. 

Dr. Matt Chalmers [00:13:53] So I think this is the one I want to read you a little bit more of the positive stuff on this from actual research, but then I read you the actual nature thing so we can kind of go break through what that means. 

Dr. Matt Chalmers [00:14:05] But let me read this one real quick. [00:14:07]Erythritol is naturally occurring safe and non-nutritive sugar alcohol, which means it doesn't affect your Function. compared to other sugar alcohols, evidence from human studies indicate that it is mostly absorbed and excreted in urine unmetabolized. [12.8s] That's important. 

Dr. Matt Chalmers [00:14:22] The fact that it's unmatched catalyzed means it came in, did nothing and left. That's that's that. That's a really big positive function as far as finding a lot in your urine. So if you take a 50 grams and none of that comes out, we have to wonder what are the metabolites or what are the breakdowns of that metabolize chemical. 

Dr. Matt Chalmers [00:14:42] And so when this says a lot of it's coming out means that it's not affecting us to a huge degree from a negative chemical standpoint. So minimal amounts reached the colon, [00:14:52]therefore it is better tolerated with less undesirable gastrointestinal effects [4.0s] it doesn't mess your stomach up . 

Dr. Matt Chalmers [00:14:59] [00:14:59]Consumption to Erythritol , does not increase circulating glucose or insulin and acute and acute clinical trials suggest it promotes gut hormone release. [10.9s] All right. So the number one thing we got to worry about when we're talking about diabetes, when we're talking about sugars, we're talking about old blood vessels and things like that is not really glucose it's really insulin. 

Dr. Matt Chalmers [00:15:22] So when we when we consume something sweet, we always look at what's the insulin responsible? What's the glycemic effect? Glycemic index. What is the insulin response? This does not create any insulin response, which is why it's so beneficial for people who have insulin damage, which is another way of looking at diabetes. 

Dr. Matt Chalmers [00:15:45] [00:15:45]The scientific evidence. Long-term controlled clinical studies conducted in both children and adults are. Scientific evidence. Demonstrating that consumption of erythritol has beneficial effects on oral health is strong with long-term controlled clinical trials conducted in both children and adults. [20.9s]

Dr. Matt Chalmers [00:16:06] In contrast, this is. This is. So. This is. This is a big deal on actually. Erythritol are saying on both sides. [00:16:15]In contrast, the long-term controlled clinical trials supporting Erythritol as a beneficial dietary component that can lower glucose levels, body weight and risk factors in patients with type two diabetes, obesity or metabolic syndrome are almost completely lacking. [17.6s]

Dr. Matt Chalmers [00:16:34] So that giant paragraph of the sentence basically says we don't have enough research long term to say whether or not we want to start switching over to this to diabetes or obesity or metabolic syndrome they just say we don't have a lot of research on that. 

Dr. Matt Chalmers [00:16:49] I can tell you we don't have research on that, but we have a lot of physiology that backs that up. So basically switching to a diet that doesn't bring sugar in your diet or in your body that doesn't cause any sort of responses is going to fix all of the things that we just mentioned, both type two, diabetes, obesity, metabolic syndrome, all those things are fixed by regulating or completely eliminating your sugar and I'll go into that detail later if you guys really want me to. 

Dr. Matt Chalmers [00:17:19] All right. [00:17:19]So the exemptions, the exceptions to the lack of information. [4.0s] Okay. So this is the stuff we do actually. Now, the excemptions are to publish trials that provide evidence that consumption of erythritol lowered HB A1C ok . 

Dr. Matt Chalmers [00:17:35] [00:17:35]A1C is a level of long-term chronic inflammation. [2.7s] This is the one that we use that people use a lot for diabetes. This is the this is a big, big deal. And it's lowering that. It's saying that it's less danger for if that's a word, it's it's less worry for. 

Dr. Matt Chalmers [00:17:53] So this is a big deal. And there's two published trials that say this. So it's not just a one off. It goes on to say. [00:18:01]And improved endothelial function in patients with type two diabetes. [3.7s] Again, back to the blood vessel. [00:18:08]This is highly beneficial to the blood vessels from what the research here is showing. [4.7s]

Dr. Matt Chalmers [00:18:14] So again, don't quit taking this. If you're diabetic, please, for the love of God, don't stop taking this because of what you just read. 

Dr. Matt Chalmers [00:18:21] Now, I'm not saying we're not going to get research in six months that shows maybe there's an issue that with a combination like the risk of all is fine. But when you mix it with this other thing, it creates a problem. We'll go over that. But as of right now, the research we have is very good for getting off sugar regardless of how you do it. And [00:18:39]if you use Erythritol, it's fine because you're off sugar and it looks like it's very beneficial to your blood vessels, not harmful. [6.9s]

Dr. Matt Chalmers [00:18:47] So, okay, affirmative deal, function, history, type diabetes. [00:18:53]These results are supported by rodent studies and in vitro studies, but still need to be confirmed. [5.5s] They want to do more research [00:19:02]in long-term randomized controlled trials that also investigate the effects of personal consumption on body weight, insulin sensitivity and risk factors for cardiometabolic disease. [9.6s]

Dr. Matt Chalmers [00:19:12] Again. Oh, yeah. They're going to be happy. We're already having the results is going to be good. It's going to be. Yes, use the research all you know, for sugar and diabetes and all these things fall back. 

Dr. Matt Chalmers [00:19:23] So. All right. There's a [00:19:25]the plausible explanation is that the plasma erythritol is a biomarker of. It says benign is benign biomarker of hip dysregulation resulting from glucose or fruitose rich diets or conditions that increase or impaired glycemia but this needs to be confirmed in clinical trials. [17.3s]

Dr. Matt Chalmers [00:19:43] So this goes back to this part of the research, goes back to what I said about Erythritol being a biomarker because you already had the damage from PPP this regulation. So as the system breaks down, it's kicking stuff out. Why not break down? Too much glucose, too much sugar. It broke and it's spilling these things out that's what you're seing. 

Dr. Matt Chalmers [00:20:04] All right. So I want to go to the actual article that the researchers are looking at this from. So I'll read you kind of the book. This is 28 pages. I swear to God, if I can read that much. It's like a page. That's all I'm going to do. 

Dr. Matt Chalmers [00:20:18] So [00:20:19]Artificial sweeteners have been widely introduced into the food chain over the past few decades to reduce sugar and chloric intake with the growing obesity epidemic worldwide artificial sweeteners are increasingly common ingredients in soft drinks, processed foods, personal care products, in fact, are for artificial sweeteners have been detected in groundwater tap water. It's all over the place. We get it. [19.4s]

Dr. Matt Chalmers [00:20:39] All right. [00:20:39]Patients with metabolic diseases, including type two diabetes and obesity, are frequently advised the use of artificial sweeteners in place of sugar can improve basic they control, [9.2s] which is true, [00:20:50]and help achieve weight loss. [0.9s] True, [00:20:52]however, there is growing epidemiological evidence linking the consumption of artificial sweeteners to adverse cardiometabolic phenotypes, which is weight gain, insulin resistance, type two diabetes, cardiovascular disease, including a erithrovic complications and cardiovacular mortality. [15.4s]

Dr. Matt Chalmers [00:21:10] On this one. We did have a little chat on this one because I think we've all seen the person who gets the piece of cake and the Diet Coke. Just because you're eating more artificial sweeteners does not mean that you've decreased your sugar intake. 

Dr. Matt Chalmers [00:21:22] So if you're eating trash and artificial sweeteners, okay, you're going to have artificial sweeteners in your blood and you're also going to have all the damage from everything else. 

Dr. Matt Chalmers [00:21:32] So that's the thing. I see this a lot. And people who have one person in the family who is doing a kilo thing and the other people are not and so guess what? Oh, those aren't good cookies. Oh, those are good snacks. I'm going to eat some, too, which is fine. You can do that. But if you're also eating a bunch of other trash, don't blame my stuff for the other stuff. So that's that's one of those things I want to toss out right here. 

Dr. Matt Chalmers [00:21:57] By the way, if you're wondering, I'm on the side of ketone. I'm on the side of ruthrottle want to throw that out to my side have you guys got that anyway. 

Dr. Matt Chalmers [00:22:06] All right. [00:22:07]Randomized clinical trials examining the long term safety of consuming artificial sweeteners have not been performed. [5.5s] And the true even for more clearly adopted forms such as aspartame and sucralose. Yeah, those were the two we actually had the research on and we've all said that they're terrible you should consume them. Full disclosure, I do like Diet Coke and I do have them on a somewhat regular basis, like, I don't know, one or two a week. Little Ada and I take stuff to balance that. 

Dr. Matt Chalmers [00:22:34] We're not arguing that all of these things are good we're saying some are good, some are bad. But let's be honest about the ones that are good and ones are bad. Sucralose and aspartame, I would not tell you. And so I. But outside of that, I know I've written about that. 

Dr. Matt Chalmers [00:22:52] So anyway, indeed, this [00:22:56]despite the growing incorporation of artificial sweeteners in the food chain, their cardiovascular risks risks have seldom been investigated. [6.2s] The degree that factor [00:23:05]erythritol is a four carbon sugar alcohol polyol that is commonly used as a sugar substitute is naturally present in low amounts, in fruits and vegetables and in people. But when incorporated into processed foods, it is typically added at levels a thousand times higher than the indulgence levels, [16.6s] which is true. 

Dr. Matt Chalmers [00:23:24] [00:23:24]For example, up to 60% of food weight in some creams or pastries are Erythritol due to the lower sweetness compared to sucrose sugar. The daily intake of erythritol. In total, the U.S. population has been estimated to reach up to 30 grams per day in some participants based on the 2013-2014 National Health and Nutrition Examination Study and FDA filings. [22.3s]

Dr. Matt Chalmers [00:23:47] Yeah, that's that's probably true. Yes, I too like ice cream, but I love that stuff. It's about 30 grams, I'd say. So. Yeah. I'm not going to tell you that 30 grams is ridiculous. People are out there being like, Well, thaty make them consum this ridiculous amount. That's I don't buy that number that my. Yeah, that's really a pretty solid average it's not a right is doing yourself is eating a whole pint of ice cream but that's not I don't think that's crazy. 

Dr. Matt Chalmers [00:24:16] Though I'm not going to subside to subscribe to the idea that the numbers that they're talking about consuming are wildly outside the box. I keep hearing people say that I. I think what you're eating is that 30 grams is pretty that's that you use to be an average day for a person. 

Dr. Matt Chalmers [00:24:31] But again, I don't want people to get hung up on that because remember, we have lots of studies that say it's really good for your heart and blood vessels. And guess what? Most people who move to a Kilo style diet will move from the standard American diet with way too much sugar. So guess what? You'll have damage to your heart, your blood vessels. So a little extra erythritol probably is a good measure. Not a bad measure though anyway. Upon investigate and find ingestion, Erythritol is poorly metabolized and mostly straight in the urine. We knew that. Consequently, Erythritol is characterized by both a zero calorie or non-nutritive sweetener as a natural sweetener because it comes from purchase up, leading to its rapidly rising popularity and predicted doubling in the market share within sweetener sector in the next five years. I 100%. Nevertheless, little is known about circulating erythritol levels and cardio metabolic risks. Early studies have implied potential benefits, including reported antioxidant potential in animal models of diabetes research with the rat study and improved improvement in endothelial function. After four weeks ingestion of the versatile containing drink in patients with diabetes that makes blood vessels better. This is in the article. This is in the article that race freaking out about. So I don't get here. People don't read everything. However, in small prospective study of plasma levels of erythritol among freshmen, college students were associated with incidence of nine months out of a three week day. Now, this is shocking, I'm sure, to everyone who's ever been to college, that's in your freshman year, you will gain fat around the midsection. Yes, that was the only population that when they looked at who was consuming erythritol who had a weight gain. For those of you who don't know, it's called the Freshman 15. It's a thing everyone knows about because when you go to college, you eat like trash and drink too much for the first year and so you gain weight. I don't even know why they're trying to pound this off on the freshman 15, but Okey dokey. And it says it took him nine months to get fat. So that's why one year anyway. In another study, Erythritol levels were associated with the onset of type two diabetes. Again, yes. If you're starting to get diabetes and you start trying to substitute your sugars, yeah, you're going to see that a lot of people like all polyols. The separation of erythritol from its structure isomer is difficult, doesn't break down, is hindering its analysis and qualification. A detailed examination of the relationship between Erythritol and both. Are you a vascular disease? CVD and a resource from complications has not been reported. Guys, this this, this research study, they don't have it. They don't have a research study that shows that it was at all cause heart attacks. They don't have it. This is, again, what it's saying in the actual document that they're all citing. It says there is no relationship, there's no complications, nothing has been reported. Nothing's been studied or reported because it hasn't happened. Again, they saw a bunch of people who had heart problems, noticed that they had a referral in our system and decided that their research all had something to do with the heart problem, which it does kind of in there. But the reason it does kind of is because as the chemistry breaks down, your body produces the erythritol and the damage to the chemistry that broke down caused your heart issue. But the reason the system broke down again was because there was too much sugar in the diet. Yeah, biochemistry and just this simple research. So I'll finish this and will be done. After his initial untargeted metabolic studies suggested circulating levels of multi polyols, especially erythritol were associated with incident three year risk for major adverse cardiovascular events, which if you read it that way, I would agree. If you look at a patient and they have a reservoir in their system and you go, Hey, you eat any erythritol foods, you think, No, I hate that stuff. You need to do other studies. You need to start looking for why they're going to have their heart attack in four years. That was the whole point of the study that they did was what biomarkers can we find that would predict a heart attack from heart damage currently going on? So if I pull someone's blood and they've got a resveratrol in it, I'm going to know they've got they're going to have problems, which is hilarious because I was not pulling it beforehand in my cardiovascular panel to detect like damage to the heart. I'm going to add it to that now. Because if they're not eating erythritol and we find it, we know that their chemistry screwed up from too much sugar and we can then fix it. So there is benefit that's come from this, at least for me. So that's what they're saying. They looked at the relationship between plasma levels of versatile and instance of mace, which is myocardial heart problems in European cohorts. So this wasn't even an American study, which doesn't matter. But that's that's basically what we're looking at. This is not something to freak out about. This is not something to quit consuming. Erythritol on. Especially now we have no the only research we have on a rooftop and heart and cardiovascular function is that we should be consuming more of it, not less. That's the actual research we have. So. Take it for what it's worth. But that's what's going on. Bring some sort of to a PC about this is because this is in all of the Quito foods. If you were trying to find a way to damage everybody's health, it might take away all of the little snacky things they could have while they're in ketosis. This would be the biggest damage you could do to those people's health 100%. And anybody who's ready to suffer in Quito understands that for the vast majority of people, I would say 40, 50% of the population of the United States should only be on keto diets. There are some who shouldn't be on keto diet. They're probably 20% of the of the ecto more sci. But everybody throughout from throughout the 60% population could do it. Maybe 65 would be healthy on it, but there's at least 40% population who 100% should be 100 akito all the time. That's why this is a big problem. If you start taking the arithmetic out of things because we had an emotional oh my gosh, we're going to we're going to damage people's hearts. So we've got to keep the research all in circulation. We've got to make sure that cancer I have access to it, because if you don't want to eat it, that's fine. Don't eat it. But for those of us who are on keto diet who want something sweet here and there, this is a really big deal. We need to leave this in and to be very cardioprotective it's going to help repair the damage through the years of not being on Quito and eating too much sugar. So this is good. This is not causing heart attacks, it is not causing stroke. Though I would say with this whole time it's pretty impressive. But yeah, so guys, don't worry about it. This has been Dr. Chalmers and our goal is to get as much accurate health and wellness information out as possible. Please subscribe and share so we can help even more people stay healthy and stay safe. You can find us on all social media at Dr. Chalmers one and Dr. Chalmers Substack. 

Erythritol 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824470/ 

This shows that a diet high in fat and protein and low in sugar with added 5% erythritol water showed decrease in body fat, lowered white fat, reduced inflammation, improved glucose tolerance, and a host of other beneficial blood changes.  

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037362/ 

Consumption of erythritol is heart and blood vessel protective. Reducing rigidity, fibrosis, and increasing dilation of extremities and capillaries.  

PPP 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329227/#:~:text=The%20pentose%20phosphate%20pathway%20(PPP,scavenging%20of%20reactive%20oxygen%20species. 

This shows the PPP or the pentose phosphate pathway. This pathway is from the metabolism of glucose and it doesn't really do good things. It feeds cancer and a host of other inflammatory, weight-gaining issues. The thing is that through this pathway, your body naturally turns sugar into erythritol. 

The 4 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824470/ 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037362/ 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329227/#:~:text=The%20pentose%20phosphate%20pathway%20(PPP,scavenging%20of%20reactive%20oxygen%20species. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470864/  

The artificial sweetener erythritol and cardiovascular event risk 

https://www.nature.com/articles/s41591-023-02223-9.epdf?sharing_token=vQTSixerBVOO6jvrGmbfu9RgN0jAjWel9jnR3ZoTv0MTnVt_Yzm2YDkmKtSZJOysYZlROr0ymfAdj9yPHH8bMVWpKjhPzPeMT8zTG9DpNMmnfRfOqNqOH8PhwI2X9sxfHMa-Tpawl-dyIWq9WdTUO2lqDJWIHLoFK3aG5AGi1YiKoK90n21Ne7KF144P4wfk183Iopz1XctzlIYs4PKFhA%3D%3D&tracking_referrer=www.cnn.com