Episode 09: MoTrPAC and the Science of Fitness

Description

In this episode, Allissa Dillman chats with researchers Malene Lindholm and Dan Katz about their work on MoTrPAC. Malene has a 20-year background in molecular exercise physiology and Dan started his medical training in cardiology and now uses high-dimensional data to understand heart failure. MoTrPAC (Molecular Transducers of Physical Activity Consortium) is a NIH-funded initiative studying exercise effects across multiple sites in the US using both human and animal studies. Dan and Malene explain what the dataset is all about, including what data is collected, from where, and the kinds of raw and pre-processed data available. They also describe how it can be accessed through various user-friendly tools for scientists of all technical abilities. Find out more at https://motrpac-data.org/ and contact them with questions at motrpac-helpdesk@lists.stanford.edu. 

Guest Bios

Daniel Katz, MD, is an Assistant Professor of Medicine in the Stanford Center for Biomedical Informatics Research (BMIR) and the Cardiovascular Medicine Divisions. He practices as an Advanced Heart Failure and Transplant Cardiologist. He completed internal medicine residency at Massachusetts General Hospital, general cardiology training at Beth Israel Deaconess Medical Center, and joined Stanford in 2021 for his advanced heart failure training. His research focuses on identifying the various pathophysiological patterns and mechanisms that lead to the heterogeneous syndrome of heart failure. His efforts leverage high dimensional data in many forms including clinical phenotypes, plasma proteomics, metabolomics, and genetics. He is presently engaged in analysis of multi-omics data from MoTrPAC, and the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program. 

Malene Lindholm, PhD, is a senior research engineer and Director of the Human Molecular Athlete Moonshot for the Wu Tsai Human Performance Alliance at Stanford University. After earning her PhD in Medicine at the Karolinska Institute in Sweden, she performed her postdoctoral studies at the Cardiovascular Institute at Stanford University. Her current research focuses on unraveling the multi-omics adaptation mechanisms to exercise across tissues and the genetic basis of extreme human performance. The ultimate objective is to transform the findings into tangible application in the field of precision exercise health and medicine.

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