What happens when a devastating brain cancer diagnosis collides with a sharp comedic mind? You get Bryan Bishop—a podcasting icon, bestselling author, and relentless advocate for cancer research. Known for his quick wit and signature humor on The Adam Carolla Show and The Bryan and Gina Show, Bryan shares how he turned his inoperable brain tumor diagnosis into a mission to uplift, inspire, and push forward groundbreaking cancer research.

On this episode of Believe in Progress, Mitch Stoller, Chief Philanthropic Officer at the AACR, sits down with Bryan, who brings both humor and heart to his journey with brain cancer.

Bryan was diagnosed with an inoperable brain tumor at age 30. He has used his voice to

raise awareness, inspire resilience, and support cancer research. His memoir, Shrinkage:

Manhood, Marriage and the Tumor That Tried to Kill Me, captures his story with both poignancy

and humor.

In this episode of Believe in Progress, Bryan discusses:

• His journey from diagnosis to advocacy
• How humor became his unexpected but powerful survival tool
• The role of support systems, including his wife and daughter
• Why raising awareness through comedy, public speaking, and storytelling is vital
• What we can all learn about resilience, purpose, and perspective

If you or someone you love is facing cancer—or if you just need a powerful reminder of the strength of the human spirit—this episode is for you.

Listen now, be inspired, and help fuel the fight against cancer by supporting AACR at aacr.org.

Episode Summary:

Guest: Bryan Bishop – New York Times Bestselling Author, Podcast Host, and Brain Cancer Advocate

Host: Mitch Stoller, Chief Philanthropic Officer, AACR Foundation

Part 1: Bryan’s Background & Diagnosis

• The Moment Life Changed – Bryan shares his shocking brain tumor diagnosis at just 30 years old.
• Laughing Through the Hardest Times – How humor became his greatest coping mechanism, fueling his resilience in both life and treatment.
• The Power of Support – A look at the crucial role of family, especially his wife, Christie, in navigating the toughest days.

Part 2: Career, Comedy & Advocacy

• From The Adam Carolla Show to The Bryan and Gina Show – How Bryan balanced entertainment and health challenges, while using comedy as an outlet.
• Becoming a Voice for Brain Cancer Awareness – Bryan’s work with The V Foundation, The National Brain Tumor Society, and The American Brain Tumor Association.
• Speaking to SpaceX, Genentech & Beyond – The powerful message of humor and resilience he shares with major organizations.

Part 3: Lessons, Legacy & The Future

• Takeaways from His Memoir, Shrinkage – Why Bryan’s journey resonates so deeply with readers and audiences.
• How Advocacy & Research Make a Difference – Bryan reflects on what he’s learned through his deep involvement in cancer research initiatives.
• What’s Next? – Bryan’s outlook on the future, his goals as a father and advocate, and advice for others facing life-changing diagnosis.

How You Can Support Cancer Research

Bryan’s story is a testament to the power of research, resilience, and the human will to fight. Help fuel life-saving cancer research by donating to the American Association for Cancer Research at aacr.org.

Check out Bryan’s bestselling memoir – Shrinkage: Manhood, Marriage, and the Tumor That Tried to Kill Me (Link: https://a.co/d/8jUWJGC)

How You Can Help in the Fight Against Cancer  

• Subscribe: Never miss an episode! Subscribe to the Believe in Progress podcast on YouTube, Apple Podcasts, Spotify, or your favorite podcast platform.  
• Share: Spread hope and awareness by sharing this episode with family, friends, and anyone facing challenges.  
• Donate: Join the fight against cancer by making a donation to the AACR at AACR.org/Donate.

Every contribution, share, and act of advocacy makes a difference. Let’s stand with Howard and fuel the fight against cancer

Cancer Research Saves Lives®

Check out more episodes of Believe in Progress at AACR.org/BelieveInProgress. 

Listen and subscribe wherever you get your podcasts.

Production Credits

Host: Mitch Stoller

Guest(s): Bryan Bishop

Executive Producer: Anthony Lopes

Executive Producer: Michael Leary

Associate Producer: Heather Holland

Director: Anthony Lopes

Creative Director/Director of Photography: Michael Leary

Editor: Michael Leary

Writer: Anthony Lopes

This episode is produced by CollegeCast LLC.