This Week in Microbiology

This Week in Microbiology


Latest Episodes

279: A Road Map For Successful Phage Therapy
January 13, 2023

TWiM describes successful phage therapy against a mycobacterial lung infection, and how encapsulation of the cell wall protects S. pneumoniae from its major peptidoglycan hydrolase and host defenses.

278: Bacteria Sing The Blues
December 29, 2022

TWiM explores the relationship between the gut microbiome and depressive symptoms, and how purine nucleotides act as adjuvants to antibiotics. Hosts:,, and Subscribe to TWiM (free) on,,,,, or b

277: To Stop or Not To Stop
December 08, 2022

On this episode of TWiM, we reveal widespread stop-codon recoding in bacteriophages that may regulate translation of lytic genes, and how Staphylococcus aureus inhibits Pseudomonas aeruginosa growth.

276: Bacterial Multicellularity Near An Underground Stream
November 24, 2022

TWiM presents evidence that over half of human pathogenic diseases are impacted by climate change, and considers how a novel prokaryote discovered next to an underground stream illuminates the pathway

275: The Myth of Clonality
November 11, 2022

TWiM reveals high rates of co-transformation of plasmids in E. coli overturns the clonality myth, and bacterial membrane vesicles as a novel strategy for extrusion of the antimicrobial bismuth in H. p

274: Bacterial Endosymbionts Block Giant Viruses
October 20, 2022

returns to TWiM to join the discussion of how to design a complex gut microbiome, and protection of protists from virus infection by intracellular bacterial symbionts. Hosts: ,, , and Become a of T

273: The Value of Wiping
September 30, 2022

TWiM reveals how to inactivate norovirus on formica surfaces, and how to achieve antibiotic resistance by suppression of a frameshift mutation in an essential gene. Hosts: ,, , and Subscribe to TWi

272: Metabolism’s Got Rhythm
September 16, 2022

TWiM explores the activation of natural product synthesis using CRISPR interference in Streptomyces, and how light/dark and temperature cycling modulate Electron Flow in Pseudomonas aeruginosa biofilm

271: Microbe vs Microbe
August 25, 2022

TWiM presents a novel mucosal COVID-19 vaccine based on a bacteriophage capsid, and potentiation of C. difficile infection severity by the gut bacterial community. Become a of TWiM. Links for this ep

270: Magnets and Salt Improve Plastics Production by Archaea
August 09, 2022

TWiM explores the use of Archaea to produce plastics from molasses wastewater, and a bacterial defense against bacteriophage infection that involves depletion of deoxynucleotides. Become a of TWiM. L