In this “Lucky 13” episode of the TPR podcast, Steven and Leon discuss naloxone, and address the following issues:

1) Does the concept of a “heroin overdose patient” have meaning anymore in this age of U-47700, fentanyl, and carfentanil?
2) Given the adulteration of both heroin and counterfeit prescription medications with extremely potent synthetic opioids, do we have to reconsider our entire approach to opioid overdose patients?
3) Can past medical literature guide us in our management of these patients?(Hint: the answer is no.)
4) What medical toxicology paper do Steve and Leon — in an unusual state of agreement — feel was the best to appear in 2016?