In this twenty-first episode, Nichola Conlon provides a scientific background, introducing sirtuins and NAD. She then explains why popular NAD+ boosters, NR and NMN, are first-gen products.

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She details how Nuchido formulated the first second-gen product by taking a novel whole systems approach. Lots of NAD, anti-aging, and nutraceutical discussion along the way.
Topics we discussed in this episode

Recent personal experience with COVID-19
Her molecular biology PhD focus
Systems pharmacology
Help from Aubrey de Gray
Disillusioned with drug development
Founding Nuchido
What are Sirtuins? What is NAD?
Importance of NAD. Why Boost NAD Levels?
Inefficiency of First-Gen NAD Supplements: NR and NMN
Three ingredients to boost NAD
Pure NAD limitations
Nicotinamide Riboside (NR)
Nicotinamide Mononucleotide (NMN)
60% increase in NAD "only"
Second-gen, demonstrated it can be done much better if you take a whole systems approach
Importance of NAD salvage pathway
PARP enzymes
Inability to power sustained high-levels because of salvage pathway deterioration
First-gen may not be great for epigenetics
Increases expression of the enzymes in the salvage pathway that are known to decline with age
Ingredients that reduce the expression of other processes that are actually wasting NAD
Enzyme called CD38
Inflammatory levels - CD38 just chews up NAD
Multiple things that you can do to fix the cell before you even need to put precursors in.
NAD decreases with age
Do we Need NAD Supplements?
Sirtuins and mitochondrial biogenesis
Boosting your NAD levels, improves mitochondrial function.
Multiple reasons that are causing the NAD to decline, boosting as with first-gen only the amount of raw material that your cell has is quite naïve
Second-gen helps fixe your body's natural ability to make and recycle its own NAD
Nuchido TIME+ boosts NAD on average by 242%, four times more than the 60% widely cited for first-gen
ChromaDex vs Elyisum Health
Terms B3, niacin, nicotinamide, nicotinic acid, NR
Abram Hoffer and orthomolecular medicine
Nicotinamide is not likely to be a sirtuin inhibitor,
How to measure NAD levels
Nuchido TIME+ ingredients
Alpha lipoic acid (ALA) and effects on AMPK
Conversion of NADH to NAD+
Drift more towards having more NADH in your cell with age
Pathway called NQO1, converts NADH back to NAD+
ALA is a really powerful antioxidant, activates NRF2
ALA vs ALA-R
Sophora Japonica Extract Rutin, senolytic
NAMP
Aging is an inflicted cascade disorder

Show links

Nuchido (Company Website)
ChromaDex (Company Website)
Elysium Health (Company Website)
Elysium Health, Inc. Loses Appeal of Patent Challenge Decision (Press Release)
Orthomolecular Medicine (Wikipedia Entry)
Abram Hoffer (Wikipedia Entry)
Niacin: The Real Story: Learn about the Wonderful Healing Properties of Niacin (Amazon, Book)
Orthomolecular Medicine for Everyone (Amazon, Book)
GlycanAge (Company Website)