In this fifteenth episode, Liz Parrish shares her quest for radical life extension and details her two completed gene therapies.

Read the transcript

She describes the regenerative medical tourism available today for increased lifespan and costs. She relates her company's mission to create a human that regenerates faster than they degenerate. She details her upcoming gene therapies, including upgraded IQ.
Topics we discussed in this episode

Making controversial medical history
Quest for radically increased longevity
Upregulating telomerase, hTERT
Downregulates myostatin, follistatin
Interest in regenerative medicine technologies
Desire to help billions of people
Comany goal to create a human that regenerates faster than they degenerate
PGC-1α
BioViva's DNA methylation kit
Plan to look at multiple aging clocks
Regenerative medical tourism
Childhood ambition
Space travel and gene therapy are intertwined
Personal goals
Morphological freedom
Hope for the future
Being of optimistic nature
Gene therapy - dystopian or utopian?
Gene therapy costs
Societal health stratification
Making humans more malleable like software
What is gene therapy?
Gene delivery and viral vectors
Next personal gene therapy - Klotho
Next personal gene therapy - PGC-1α
Developing New Viral Vectors
Apo-A1 Milano
Adeno-Associated Virus (AVV. AAV-2)

Show links

BioViva (Website)
Integrated Health Systems (Website)
Telomeres and Longevity: A Cause or an Effect? (Paper)
Effects of Myostatin Deletion in Aging Mice (Paper)
Telomeres and Telomerase as Therapeutic Targets to Prevent and Treat Age-Related Diseases (Paper)
Inhibition Of Myostatin With Emphasis On Follistatin As A Therapy For Muscle Disease (Paper)
PGC-1α in Aging and Anti-Aging Interventions (Paper)
TimeKeeper™ DNA Methylation kit (Landing Page)
Longevity (Subreddit)
Maximum Life Foundation (Website)
George Church (Wikipedia Entry)
Factor IX (Wikipedia Entry)
hTERT (Wikipedia Entry)
Hayflick Limit (Wikipedia Entry)
Follistatin (Wikipedia Entry)
The Longevity Hormone Klotho Is a New Player in the Interacion of the Growth Hormone/Insulin-Like Growth Factor 1 Axis (Paper)
rs9536314/Klotho Gene (SNPedia Entry)
PGC-1α in Aging and Anti-Aging Interventions (Paper)
María A. Blasco (University Staff Page)
The Long Saga of Apo-A1 Milano (Article)
Why Most Published Research Findings Are False (Paper)