Los Angeles Rams vs San Francisco 49ers Predictions, Picks, and Odds for their showdown on Sunday, October 13 from Los Angeles Memorial Coliseum, Los Angeles. Direct from Las Vegas, the WagerTalk handicapping crew look at the Vegas odds and give their NFL football expert picks and predictions on the matchup between the Rams and 49ers. Current Vegas NFL football odds have the Los Angeles Rams favored by 3.5 over the San Francisco 49ers (updated NFL spreads and totals from Vegas http://www.wagertalk.com/livelines).