Rescue Express is a non-profit rescue tranport service that every two weeks hauls up to 400 homeless pets from Southern California and the Central Valley to rescues and shelters in the Pacific Northwest that have more adopters available than animals available for adoption.
Donate to Rescue Express
They also transport from Texas to Minnesota and plan to expand to the East Coast.

Continued emphasis on spaying/neutering pets and new emphasis on transport programs, such as Rescue Express, have the potential to turn the U.S. into a no-kill nation.

Since 2015, Rescue Express has saved more than 20,000 homeless pets. In 2018, the volunteer group transported 8,600 animals, mostly canines. Here's how the group describes itself:

"Rescue Express, a DBA of MGM Animal foundation, is a free- of-charge shelter animal transporter for over 300 shelters, rescue organization, and individuals.
We operate every weekend, travelling from San Diego, CA to Burnlington, WA. We operate buses with 100 carriers aboard and a tractor trailer with a 300 carrier capacity. The animals are picked up from shelters between San Diego and Redding, CA. and are received by non-kill shelters and rescue groups between Eugene, OR and Burlington, WA."
If you drive Interstate 5 on the weekend, you are almost certain to eventually see the Rescue Express tractor-trailer rig. They start in San Diego early Saturday and finish in Washington state early Sunday.
Since its founding in 2015 by software entrepreneur Mike McCarthy, Rescue Express has faced challenges. Mostly money challenges.
In this podcast, McCarthy says each transport run costs about $4,000. At one time, the group charged for transporting animals with the sending organizations paying. I would think the receivers -- who eventually charge adoption fees -- would be better able to pay.
Donate to Rescue Express
Sure spot in heaven: Rescue Express Founder Mike McCarthy
I must be wrong, though, and Rescue Express now operates as a free service, counting on donations to cover their bills.
That's tough sledding because infrastructure non-profits are generally invisible to the large donor community and miss out on badly-needed money.
Continued emphasis on spay/neuter and new emphasis on transport programs, such as Rescue Express, have the potential to turn the U.S. into a no-kill nation.
Transport is critical and Mike McCarthy's desire to do right by animals has saved thousands of lives and promises to save many thousands more.
Please listen to the podcast and support Mike and Rescue Express. It is a very important project.