The Cleveland Clinic Heart, Vascular and Thoracic Institute celebrates the 2000th transplant. Cleveland Clinic began innovative work on heart transplants in 1968, with the official beginning of the program in 1984. On average, Cleveland Clinic performs 50-60 transplants per year, including between five to eight pediatric transplants per year. The Cleveland Clinic’s program directors discuss the program overall, how pediatric and adult transplant teams work together, challenges and factors in the program’s success, response to COVID, and innovations in care.