In this thirteenth episode, Tom Stubbs, Co-Founder/CEO of Chronomics starts with introducing epigenetics. He describes the technology and expertise that he's brought together to create the only company in the world advancing the forefront of epigenetic biomarkers.

Read the transcript

He explains how their A.I. based health biomarker engine will be used to reduce your risk of future illness.
Topics we discussed in this episode

Focus of Chronomics
Epigenetic sequencing
Epigenetic ideal data type for preventive health
Epigenetics ideal for figuring out age-related and chronic conditions
Genomics and epigenetics provide complimentary data
Histone methylation
DNA methylation
MTHFR gene
CpG sites
Chronomics health biomarker engine
Epigenetics and aging
Blood vs saliva as an epigenetic sampling type
Arrays vs next-generation sequencing
Why epigenetics is a fantastic data type
Developing unique epigenetic signatures or biomarkers
Polygenic risk scores
Biological age and epigenetic clocks
Using blood vs saliva for epigenetic clock input
Arrays vs sequencing for epigenetic clock input
Genetics vs epigenetics
Leveraging epigenetics to personalize pharmaceutical agent or drug intervention risk/reward
Leveraging epigenetics to personalize rejuvenation therapy or longevity compound reward decisions
Ending flying blind as to whether things have a positive impact or a negative impact on your health
Providing people with access to their molecular level biological data
Ability to retain that immortality across the human existence
Epigenetics in utero mechanisms
Epigenetics across generations
Epigenetic memory
IPS reprogramming
Dietary interventions on rate of biological aging

Show links

Chronomics (Website)
Tommy Wood on Engineering Sustained Health Using A.I. & Standard Blood Chemistry (Podcast Guest #006)
What is 30x and 0.4x Whole Genome Sequencing? (Article)
Next-Generation Sequencing vs. Microarrays (Article)
100,000 Genomes Project (Wikipedia Entry)
From Metabonomics to Pharmacometabonomics: The Role of Metabolic Profiling in Personalized Medicine (Article)
Homocysteine and MTHFR Mutations (Article)
CpG site (Wikipedia Entry)
Polygenic Score (Wikipedia Entry)
Epigenetic Clock (Wikipedia Entry)
Steve Horvath (Wikipedia Entry)
Jeff Kaditz on Multiscale Digital Models of Human Biology, Turning Health into a Hard Science (Podcast Guest #012)
The Epigenetic Landscape in the Course of Time: Conrad Hal Waddington's Methodological Impact on the Life Sciences (Paper)
Induced Pluripotent Stem Cell (Wikipedia Entry)
Beta Oxidation (Wikipedia Entry)
Cell Potency (Wikipedia Entry)
Steve Horvath (Wikipedia Entry)
Dutch Famine of 1944–45 (Wikipedia Entry)
Gamete (Wikipedia Entry)
From Germline to Soma: Epigenetic Dynamics in the Mouse Preimplantation Embryo (Paper)