In this behind-the-scenes (BTS) interview, we sit down with Kevin Spelman, PhD, a molecular biologist and medicinal plant expert that has spent time studying the endocannabinoid system (ECS) and how medicinal plants affect the ECS. In this interview we discuss how to think about the “entourage effect”, biases in science against medicinal plant research, the safety and efficacy of medicinal plants and dietary supplements, misconceptions about Cannabis, and much more! Stemming from the release of episodes 4 and 5 of the podcast where we explore the concept of Cannabis as a medicine, this interview contains a lot of content that got cut from those episodes for time that many of you will likely enjoy.